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Cannabidiol or CBD may prolong the effects of sildenafil (Viagra) — but is this combination safe? What are the risks? CBD can interact with many medications, including sildenafil (Viagra). Read on to learn if you can take CBD oil together with Viagra. As it turns out, CBD oil could work wonders in the bedroom. Let’s get a little more intimate with the long list of potential benefits of CBD for sex.

Does CBD Interact With Sildenafil (Viagra)?

Cannabidiol or CBD may prolong the effects of sildenafil (Viagra) — but is this combination safe? What are the risks?

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Sildenafil (Viagra) is used in the treatment of erectile dysfunction (ED).

Cannabidiol (AKA CBD) is primarily used to manage chronic pain, anxiety, or insomnia — but it has many other health benefits as well.

Some people report using CBD alongside sildenafil to boost its effects — helping to increase erectile function and eliminate concomitant issues like performance anxiety.

Is this combination safe? What are the risks of taking CBD with Viagra (sildenafil)?

Table of Contents

Does CBD Interact With Sildenafil (Viagra)?

Yes. CBD can interact with sildenafil (Viagra) and should be used with caution.

The main concern with using CBD and Viagra is an increased risk of side effects. While uncommon, Viagra can lead to headaches, dizziness, indigestion, and a condition called priapism which involves painful and long-lasting erections.

CBD may also prolong the effects of Viagra by slowing down the body’s ability to eliminate it.

Let’s explore each type of interaction more closely.

A) Slowed Elimination (Metabolic Inhibition)

Drug metabolism occurs in the body due to the effects of a group of enzymes from the P450 family. Metabolic inhibition occurs when two drugs need the same enzymes to get metabolized. Hence, they end up competing against each other for the said enzymes. This action could result in slowing down the metabolism of one or both drugs.

Sildenafil is extensively metabolized by CYP450 enzymes, especially CYP3A4 (major route) and CYP2C9 (minor route). CBD also gets metabolized by these same enzymes.

Because of this ability, if CBD and sildenafil are taken together, the plasma levels of sildenafil can rise in the body. This only becomes dangerous if Viagra is used continuously on a daily basis. Over time, concentrations of the drug can build up to dangerous levels. It’s important to allow enough time between doses for it to be cleared from the body.

B) Increased Effect (Agonistic Interaction)

An agonistic interaction occurs when two or more items exhibit the same effect on the body.

In the case of CBD and sildenafil, the shared effect focuses on blood vessel dilation. Both CBD and sildenafil cause the blood vessels to relax. This could lead to symptoms of excessive relaxation, which include dizziness, headaches, and priapism.

Other Names For Sildenafil(Viagra)

Sildenafil is sold under many different names. All share the same risk and potential interactions.

Other names for sildenafil include:

  • Alsigra
  • Aryagra
  • Caverta
  • Edegra
  • Giagra
  • Medigra
  • Penegra
  • Revatio
  • Silagra
  • Vega
  • Vizarsin
  • Xcite
  • Zenegra

Similar Medications: CBD & Erectile Dysfunction Medications

CBD and erectile dysfunction medications (PDE5 inhibitors) all carry the same level of risk for interaction. Most ED medications work through the same mechanism and require metabolism by the same enzymes in the liver.

Here’s a list of similar medications that share a similar level of risk when combined with CBD:

Is It Safe to Take CBD & Sildenafil (Viagra) Together?

The interaction between sildenafil and CBD is considered mild.

However, because of the severity of one side effect in particular (priapism), it’s wise to speak to your doctor before taking CBD alongside your prescription Viagra.

To further reduce your chances of experiencing interactions, it’s wise to separate the doses of each substance by about 2 hours.

If you experience any problems or concerns, contact your physician immediately.

Is CBD A Viable Alternative to Sildenafil (Viagra)?

CBD is not considered a viable alternative to sildenafil.

Cannabidiol and other cannabinoids have been shown to improve ED in some individuals, but this effect relies more heavily on the effects of CBD for reducing anxiety conditions (such as performance anxiety).

Sildenafil targets the blood vessels directly feeding blood flow to the penis. This effect is not found in studies exploring the effects of CBD.

For people who may be experiencing mild forms of ED or could trace the cause of their ED to anxiety, CBD could be a safer alternative. However, people who experience ED as a result of mechanical dysfunctions are unlikely to find CBD even remotely as effective for managing symptoms as sildenafil.

What is Sildenafil (Viagra)?

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor. Viagra is one of its brand names. It’s used in the treatment of erectile dysfunction and pulmonary hypertension.

It is an FDA-approved drug and is sold as a prescription-only drug in most countries.

Sildenafil (Viagra) Specs:

Drug Name Sildenafil
Trade Names Viagra, Silagra, Alsigra, Aryagra, Caverta, Edegra, Giagra, Medigra, Penegra, Vega, Xcite, Zenegra, Revatio, Vizarsin
Classification Phosphodiesterase 5 inhibitor
CYP Metabolism CYP450 enzymes, especially CYP450 3A4(major route) and CYP2C9 (minor route)
Interaction With CBD Metabolic inhibitor, Agonistic
Risk of Interaction Mild

What Does Sildenafil (Viagra) Do?

Sildenafil works by inhibiting phosphodiesterase 5 (PDE5). Its main action is to increase the blood flow to a flaccid penis. This ability causes it to get erect. Sildenafil does this by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). PDE5 is commonly found in corpora cavernosa, vascular smooth muscles, visceral smooth muscles, and platelets.

Originally developed as a potential blood pressure medication, sildenafil’s ability to cause erection in patients with erectile dysfunction was accidental but a very welcome one. This discovery caused it to become one of the most valuable methods to treat ED.

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Generally, in sexual intercourse, after an adequate amount of foreplay, there will be a release of nitric oxide (NO) from nerve terminals and endothelial cells. This action releases cyclic guanosine monophosphate (cGMP) too.

The cGMP’s release causes the muscles of corpora cavernosa in the penis to relax and the blood vessels to get dilated. It leads to a rapid entry of blood into those vessels, causing the penis to engorge, grow large, and get erect. The penis stays so until the end of the intercourse and until after ejaculation occurs.

The enzyme PDE5 prevents blood vessels in the penis from relaxing. It does this by causing the degradation of cGMP. In most ED patients, the blood vessels in the penis are also affected and lose their ability to relax properly or have some obstructions in them.

Sildenafil inhibits PDE5, increases the level of cGMP in the corpus cavernosum, allows more blood to flow into the penis, and causes the penis to get erect long enough to have sex.

However, sildenafil needs proper sexual stimulation to do its work. With a relaxed mind and good sexual stimulation, this drug may work even better.

Apart from the presence of PDE5 in the corpus cavernosum of the penis, PDE5 is also present in the pulmonary vasculature. Hence, sildenafil can increase cGMP within pulmonary vascular smooth muscle cells and cause them to relax. In patients with pulmonary arterial hypertension, this can lead to vasodilation of the pulmonary vascular bed and systemic circulation.

It is not recommended for use in women and children. Sildenafil does not cause dependence and addiction. This drug may show mild to dangerous interactions when combined with some medications. These include nitrates, antihypertensive medications, guanylate cyclase stimulators, antacids, CYP3A4 inhibitors, and CYP3A4 inducers. Sildenafil should not be used with these medications.

Sildenafil is not recommended for consumption alongside alcohol of any form. It must be avoided in users with severe heart disease, hypersensitivity to sildenafil, priapism, severe renal and liver disease, stomach ulcers, retinitis pigmentosa, and blood disorders.

Side Effects of Sildenafil (Viagra)

  • Headaches
  • Tingling sensation in the limbs and extremities
  • Hot flushes
  • Abdominal pain
  • Bluish tinted vision
  • Loss of vision
  • Sensitivity to light
  • Nasal blockage
  • Back pain
  • Nausea
  • Abnormal vision
  • Skin rash
  • Dyspepsia
  • Diarrhea
  • Muscle pain
  • Prolonged and painful erection

Key Takeaways: Is it Safe to Take Sildenafil (Viagra) With CBD?

CBD can slow down the metabolism of sildenafil in the body — potentially causing it to remain active in the body for a longer duration.

Additionally, CBD may potentiate some of the effects of Viagra, leading to a higher risk of side effects (especially dizziness and priapism).

Always consult with your doctor before taking CBD if you’ve been given a prescription for Viagra or another version of sildenafil (the active ingredient in Viagra).

CBD and Viagra (Sildenafil) Interactions: Do They Mix?

CBD (or cannabidiol) is primarily used for anxiety, depression, chronic pain, and sleep — but it also offers a wide range of other therapeutic effects.

Some people report increased effectiveness of sildenafil (Viagra) after taking CBD oil — helping improve erection and reduce worries linked to performance anxiety.

But can you safely take CBD oil with Viagra?

That’s the question we’ll answer in this article.

Does CBD Interact with Sildenafil?

Yes, and you should exercise caution when taking CBD oil with sildenafil (Viagra).

The main danger of combining CBD with Viagra is associated with an increased risk of side effects. Although uncommon, Viagra can trigger indigestion, dizziness, headaches, and priapism — a condition involving painful and long-lasting erections.

CBD may also extend the effects of Viagra by slowing down its metabolism.

Types of Interactions Between CBD and Viagra (Sildenafil)

CBD’s ability to inhibit the activity of liver enzymes creates a risk of negative interactions because it alters drug metabolism.

You can experience two types of interactions between CBD and Viagra depending on the dosage.

A) Agonistic Interaction (Increased Effect)

An agonistic interaction occurs when two compounds have the same effects on the body. When it comes to taking CBD and sildenafil together, they share the ability to relax blood vessels. Combined doses of both substances may lead to excessive relaxation, including headaches, dizziness, fatigue, and the aforementioned priapism.

B) Slowed Elimination (Metabolic Inhibition)

Drugs are metabolized in the body through special enzymes known as the Cytochrome P450 (CYP450) family.

Metabolic inhibition is triggered when two drugs target the same enzymes — leading to competitive interactions. In other words, taking CBD with Viagra could result in slowing down the metabolism of one of the drugs.

Sildenafil uses CYP450 enzymes, specifically CYP3A4 (major route) and CYP2C9 (minor route). CBD is a potent inhibitor of these enzymes.

If you take CBD with sildenafil, the plasma levels of the drug can increase in the body. When you use viagra on a daily basis, the continuous buildups of the substance could become dangerous.

You can avoid it by spacing out the time between your doses so that your body can flush them.

Other Names for Viagra (Sildenafil)

Sildenafil is an umbrella term for a pharmaceutical compound that is used to treat erectile dysfunction.

It has many different brand names, such as:

  • Alsigra
  • Aryagra
  • Caverta
  • Edegra
  • Giagra
  • Medigra
  • Penegra
  • Revatio
  • Silagra
  • Vega
  • Vizarsin
  • Xcite
  • Zenegra

Does CBD Oil Interact with Other Erectile Dysfunction Medications?

In general, always look out for unintended interactions between CBD and other medications. Since CBD and erectile dysfunction medications (PDE5 inhibitors) are metabolized by the same enzymes, they share a similar risk for interaction.

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The following medications can negatively interact with CBD:

  • Avanafil (Stendra)
  • Mirodenafil (Mvix)
  • Tadalafil (Cialis)
  • Udenafil (Zydena)
  • Vardenafil (Levitra, Staxyn, and Vivanza)

Is It Safe to Take CBD Oil Together With Viagra?

There are no clinical reports of dangerous side effects caused by interactions between CBD oil and Viagra.

However, it’s wise to maintain caution with one side effect (priapism). Since both substances can relax blood vessels, you’re theoretically at a higher risk of developing this condition.

If you notice any distressing reactions after taking CBD oil with sildenafil, discontinue the use and contact your doctor immediately.

Is CBD a Good Alternative to Viagra (Sildenafil?)

CBD isn’t considered a viable alternative to Viagra because it’s not an acknowledged ED treatment.

CBD and other cannabinoids have demonstrated benefits for ED in some individuals, but this effect is more related to CBD’s impact on anxiety disorders, such as performance anxiety.

VIagra, on the other hand, directly relaxes blood vessels, pumping more blood to the penis. This effect hasn’t been observed in studies investigating the effects of CBD.

If you experience mild ED caused by anxiety, CBD could be a safer alternative to viagra. However, ED triggered by mechanical injuries is unlikely to benefit from CBD.

What is Viagra?

Viagra is one of the brand names for sildenafil — a phosphodiesterase type 5 (PDE5) inhibitor. Doctors prescribe it to treat erectile dysfunction and pulmonary hypertension.

It’s an FDA-approved treatment for ED and is available only for a prescription in most countries.

Viagra (Sildenafil) Details:

Pharmaceutical Name Sildenafil
Brand Names Viagra, Silagra, Alsigra, Aryagra, Edegra, Revatio, Penegra, Xcite, Vega, Giagra, Vizarsin, Zenegra, Caverta
Class of Drug Phosphodiesterase 5 Inhibitor
Metabolic Enzymes Cyp 450 enzymes (CYP3A4 and CYP2C9)
Interaction with CBD Agonistic, metabolic inhibitor
Strength of Interaction Low

How Does Viagra Work for Erectile Dysfunction (ED)?

Sildenafil (Viagra) is the inhibitor of phosphodiesterase 5 (PDE5). Its main mechanism causes an increase in the blood flow to a flaccid penis. This feature enables erection.

PDE5 is an enzyme commonly found in vascular smooth muscles, visceral smooth muscles, platelets, and cavernosa.

Was Viagra Always Used to Treat ED?

Viagra was originally meant to serve a different purpose. It was invented as a potential blood pressure medication. Its side effect, however, made it a preferred drug for ED.

The Mechanism Behind Erection

When you have sex with your partner, an adequate amount of foreplay should lead to a release of nitric oxide (NO) from the nerves and endothelial cells. This event triggers the release of cyclic guanosine monophosphate (cGMP).

The cGMP’s release relaxes the muscles of corpora cavernosa in the penis, dilating the blood vessels. As the blood flows rapidly into those vessels, the penis becomes enlarged and gets erect. This state lasts until the end of the sexual intercourse or after ejaculation.

What Happens When You Take Viagra

The enzyme PDE5 blocks the additional blood flow to the vessels in the penis. It does so by causing the cGMP levels to degrade. In the majority of ED patients, the dysfunction also affects the blood vessels in the penis.

Since Viagra inhibits PDE5 and increases the level of cGMP, it lets more blood flow into the penis, allowing for a successful erection.

With a positive mindset and sufficient sexual stimulation, this drug may be even more effective.

Viagra isn’t recommended for use alongside alcohol. Patients with severe heart disease, priapism, several renal and liver disease, blood disorders, retinitis pigmentosa, and hypersensitivity to sildenafil should steer away from viagra, too.

Although Viagra doesn’t cause dependence and addiction, it can interact with several medications, including antacids, guanylate cyclase stimulators, CYP3A4 inducers, and CYP3A4 inhibitors.

Side Effects of Viagra

  • Abdominal pain
  • Abnormal vision
  • Back pain
  • Diarrhea
  • Dyspepsia
  • Hot flushes
  • Headaches
  • Loss of vision
  • Nausea
  • Skin Rash
  • Muscle pain
  • Bluish tinted vision
  • TIngling sensation in the limbs

What is CBD Oil?

CBD oil is an oily extract derived from cannabis. It can be extracted from hemp and marijuana, but most CBD oils on the market come from hemp. That’s because hemp is legal in all 50 states.

CBD doesn’t get you high, but it comes with a myriad of health benefits. This feature makes CBD an appealing alternative to marijuana. Since THC can make users anxious in higher doses, some of them are afraid of starting the treatment. CBD comes in handy here.

Since CBD is fat-soluble, manufacturers suspend it in a carrier oil. Usually, it’s MCT oil because it contains the highest percentage of saturated fatty acids.

People commonly use CBD oil for pain relief or to reduce anxiety, depression, and sleep problems. However, CBD also has the potential to manage the symptoms of autoimmune diseases and neurological conditions.

In a 2009 article published in the journal Annals of the New York Academy of Sciences, the authors concluded that the endocannabinoid receptors occur in the sexual reproductive organs, such as testicles. They also found them in the brain.

Other studies found that cannabinoids such as CBD and THC may increase libido and improve sex life in general, while others warn that regular cannabis use may lower sex drive in males. However, these studies also involved high-THC cannabis (marijuana).

One of the best-researched areas of the therapeutic use of CBD is anxiety. CBD may improve libido by reducing anxiety disorders, such as performance anxiety — increasing one’s desire for sex.

Final Verdict: Can You Take CBD Oil with Viagra?

CBD can inhibit the metabolism of Viagra in the body — potentially increasing the duration and concentration of the drug in the body.

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In addition, CBD may strengthen some of the effects of Viagra, increasing the risk of lightheadedness and painful erection.

Always talk to your doctor before taking CBD oil with Viagra. Doing so will help you find the right dosage and timing for both products and avoid potential interactions.

Sources:

  1. Carvalho, R. K., Andersen, M. L., & Mazaro‐Costa, R. (2020). The effects of cannabidiol on male reproductive system: A literature review. Journal of Applied Toxicology, 40(1), 132-150.
  2. Pizzol, D., Demurtas, J., Stubbs, B., Soysal, P., Mason, C., Isik, A. T., … & Veronese, N. (2019). Relationship between cannabis use and erectile dysfunction: a systematic review and meta-analysis. American journal of men’s health, 13(6), 1557988319892464.
  3. Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836
Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

CBD for Sex: Why CBD Oil Should Have a Place in Every Bedroom

For years, we’ve been boasting about the many physical and mental health benefits of CBD. From stress and anxiety-relief to muscle relaxation, you’re probably familiar with the basics by now. We’re here to talk about something different today… CBD for sex! As it turns out, on top of everything else, cannabidiol could work wonders in the bedroom. Let’s get a little more intimate with the potential benefits of CBD for sex.

Does CBD Oil Improve Libido?

There’s tons of research in the works right now that might provide us with better answers when it comes to CBD oil and the libido in the near future. Here are some of the latest theories about CBD’s effect on sex drive:

Less Stress, More Sex
High levels of the stress hormone, known as Cortisol, have been proven to lower your sex drive and get in the way of intimate activities. CBD oil’s magical ability to make stress melt away can have a positive impact in the bedroom by dropping Cortisol levels and helping you relax before the act. For many, anxiety and stress tend to play a role in sex; CBD can help ease some of that stage fright, getting rid of any mental blocks potentially getting in the way.

The Science of CBD for Sex
Extensive studies have shown a close relationship between CBD and the ECS (Endocannabinoid System). We won’t get into the nitty gritty of this super complex network, but one of its functions is to regulate hormone health. Essentially, we have ECS receptors throughout our bodies (including our sexual organs) that CBD binds to. This bind helps balance hormones, which ultimately leads to an increased libido.

While were on the topic of sex science, CBD also works by increasing our body’s production of a chemical called anandamide, which helps release Oxytocin aka the “love hormone.” These elevated levels tend to have a positive effect on all social interactions, including sexual encounters.

Pain-Free with CBD Unfortunately for many, including up to 40% of women, painful sex can ultimately be an issue in the bedroom. Another awesome benefit of CBD, is its pain-relieving properties. A recent study, which surveyed 5,398 Americans and focused on 502, found that “26% use CBD to alleviate pain and soreness after sex. Of those, 39% found CBD “moderately to very” effective, 59% found it “slightly to somewhat” effective, and only 2% found it non-effective.” Turns out, the pain-relief, coupled with increased blood flow and more relaxed muscles, has proven to be a pretty great combo for improving sexual activities.

How to Use CBD Oil for Erectile Dysfunction

It’s estimated that some 30 million men in America suffer from Erectile Dysfunction. While we’re not exactly sure what CBD oil does for ED (scientists think it has to do with lowered stress and increased blood flow), some men have sworn it leads to longer-lasting sex and erm… an upward trend in alleviating ED. For those wondering, there’s no specific way to use CBD oil for Erectile Dysfunction; a couple of drops beneath the tongue, 30-40 minutes in advance, should do the trick. As with anything, there can be too much of a good thing. Some studies have shown that chronic use of CBD could actually lower sex drive, whereas intermittent use could give it a much-needed boost.

CBD as a Lubricant

Can you use CBD as a lube? Absolutely! An added benefit of CBD for sex is that it can act as a lubricant between the sheets. Not only is it an all-natural alternative to chemical-based lubes, but CBD also has amazing anti-inflammatory properties, which could make sex more comfortable for both parties. There’s no such thing as the “best CBD oil for the libido,” so feel free to use any Fusion CBD oil on its own or try adding a couple of drops to your favorite lube, or try our newest product, His & Her Pleasure, a CBD-infused lubricant that has multiple benefits in bed for both partners.

Want to try something different tonight by adding CBD to your bedroom routine? Shop Fusion’s 100% pure, organic CBD products.

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