CBD oil has been shown to possess antimicrobial properties, particularly useful in attacking bacteria that are resistant to traditional antibiotics. There is no known interaction between cannabis and amoxicillin. CBD and THC may interfere with or even add to the efficacy of other antimicrobials.
CBD Oil and Antibiotics – August 2022
Antibiotics are used to prevent or treat specific types of bacterial infections. In some cases, they are prescribed for an infection that keeps coming back or causes an increased risk of complications.
However, antibiotics are not effective against viral infections, such as the common cold or flu (1 ) .
Can CBD Be Taken With Antibiotics?
There is no known interaction between CBD (cannabidiol) and antibiotics. However, there is a potential risk when combining CBD and antibiotics, as both are metabolized (broken down) through the cytochrome P450 enzyme system (2 ) .
Due to how antibiotics are metabolized, the concentrations of these drugs could potentially increase when taken with CBD.
The CYP450 liver enzymes are responsible for breaking down toxic compounds, including over 60% of any over-the-counter or prescription drugs consumed.
Certain substances can affect processing times within this system, making drugs metabolize faster or slower than they would on their own.
Cannabidiol can inhibit the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times , resulting in potentially higher levels over a longer period of time (3 )
Antibiotics use the cytochrome P450 enzyme system and can interact with CBD, as reiterated by authors Eileen Konieczny, RN, and Lauren Wilson, in their book, Healing with CBD (4 ) .
Until studies that specifically look at how CBD interacts with antibiotics are completed, talk with a doctor to make sure there are no CBD drug interactions with other medications currently taken.
CBD Oil As Antibiotic: What the Research Says
CBD oil has been shown to possess antimicrobial properties, making it another tool for fighting infection.
Although it is not well-understood how CBD oil fights bacteria, studies have confirmed CBD’s antibiotic properties, which are particularly useful in attacking bacteria that have become resistant to traditional antibiotics.
One such study investigated how various cannabinoids, including CBD and tetrahydrocannabinol (THC), affect pathogenic bacteria (5 ) .
In the said study, each cannabinoid was tested against six strains of the antibiotic-resistant superbug, methicillin-resistant Staphylococcus aureus (MRSA). All cannabinoids showed potent activity against a variety of MRSA strains.
The results of the study indicated that CBD has proven to be effective at fighting one of the most treatment-resistant strains of bacteria the field of medicine has ever seen.
Then, the researchers at the University of Queensland’s Institute for Molecular Bioscience discovered in 2019, through a series of test-tube experiments, that CBD could kill numerous strains of bacteria, including treatment-resistant strains like VRSA , VISA , and MRSA (6 ) .
These strains have developed resistance to other existing Food and Drug Administration (FDA)-approved antibiotics over the years. However, they did not develop any resistance to CBD.
In one of the experiments, the researchers found that despite exposing the strains to CBD for 20 days, this cannabis compound was able to outmaneuver the entire process of superbug development.
Moreover, CBD was found to be effective at disrupting biofilms, a microscopic conglomeration of bacteria, mucopolysaccharides, and waste products and act as a physical barrier that prevents antibiotics from working against the bacteria growth that leads to difficult-to-treat infections. This breakthrough in microbiology could ultimately lead to the development of new treatments.
Lead author, Mark Blaskovich, stated there was no doubt CBD possessed a unique mechanism that worked against bacteria resistant to other antibiotics. He admitted, however, that he and his team still could not explain how this mechanism works.
A later study , conducted in August 2019 by scientists from the United Kingdom, has shed light on the workings of that unique mechanism (7 ) .
In the said study, which was published in Frontiers in Cellular and Infection Microbiology, the authors examined the antibacterial effects of CBD and Escherichia Coli bacteria (E. coli)’s membrane vesicles, which the bacteria use to spread and communicate.
The researchers discovered that the antibiotic’s ability to prevent the release of those membrane vesicles is enhanced by CBD.
The results suggested that CBD could help fight specific bacteria as a tailored co-application with selected antibiotics.
The researchers concluded that CBD might help increase antibiotic activity and reduce antibiotic resistance when used in tailored co-application.
The results of the studies demonstrating CBD’s antibiotic properties are especially exciting for the CBD community.
However, it is essential to note that researchers still do not know what made CBD powerful at fighting the infections during the experiments.
All the research was carried out in a lab, in test tubes and on bacteria cultures, not on humans.
To date, there has been no study that recommends taking CBD with antibiotics. Neither is there a study that suggests CBD can replace antibiotics in the treatment or prevention of some types of bacterial infections.
Further research needs to be conducted to study the long-term side effects and resistance of CBD as an antibiotic.
Before taking CBD or any CBD products to treat or prevent any infection, do research and consult with a doctor experienced in cannabis use for advice.
Should You Use Cannabis If You’re Prescribed Amoxicillin?
There are no known drug interactions between amoxicillin and cannabis. Many physicians recommend that you stop using cannabis or other substances like alcohol to reduce the chances of over-sedation and give your body the best chance of fighting the infection. Cannabis and cannabinoids do, however, interact with cannabinoid receptors in the immune system so that they may affect the efficacy of some types of antibiotics.
What Is Amoxicillin?
Amoxicillin (α-amino-p-hydroxy benzylpenicillin) belongs to the beta-lactam family of antibiotic prescription medications. Amoxicillin is a semi-synthetic derivative of penicillin. Compared to penicillin, amoxicillin is effective against a broader spectrum of bacteria. Amoxicillin is sold under hundreds of different trade names, including Amoxil, Amoxicot, Dispermox, Moxilin, Trimox, and Moxatag.
Uses and How It Works
Amoxicillin is used for its antibacterial effects on many health problems, including skin infections, ear infections, stomach infections, respiratory infections, Salmonella infections, and urinary tract infections (UTIs). It is an antibiotic commonly used in medical settings.
Amoxicillin attaches to the cell wall of susceptible bacteria, inhibiting cross-linkage between the linear peptidoglycan polymer chains that make up a significant component of the bacterial cell wall, causing bacteria to die. Amoxicillin is also a bactericidal compound used in soils to prevent crop infections. However, this practice has potentially harmful effects on soil biodiversity and crop yield.
Potential Benefits and Risks of Mixing Cannabis and Amoxicillin
Although there is no known interaction between amoxicillin and cannabis, it is worth keeping in mind that we have not studied potential interactions between cannabis and antibiotics in great detail.
due to overuse is a pressing health problem. Cannabinoids in cannabis, including cannabigerol (CBG) and CBD, have displayed significant antiviral, anti-fungal, and anti-bacterial properties that could help reduce reliance on antibiotics.
- Cannabinoids have anti-inflammatory and pain-relieving effects that could help battle infections.
- Medical marijuana use may help overcome some side effects of amoxicillin, such as abdominal cramps, back, leg, and stomach pain, nausea, and vomiting.
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- Cannabinoids in cannabis, such as cannabidiol (CBD) and tetrahydrocannabinol (THC), have immunomodulatory effects that impact how the body deals with inflammation. Although there is no known interaction between penicillin-based antibiotics like amoxicillin and cannabis, theoretically, cannabis may interfere with the efficacy of some types of anti-microbial medication.
- The anti-inflammatory effects of cannabinoids are not always a plus, as they could dampen the inflammation-fighting power. This could lead to a decreased clearance of viral or bacterial infections.
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What to Do If You Need to Use Both Amoxicillin and Marijuana
There is no known negative interaction between amoxicillin and cannabis use, so if you need to use both simultaneously, you may be able to do so safely. However, for those using cannabis for non-medical purposes, doctors may recommend that you stop using it for the duration of your treatment to reduce the chances of any interference occurring.
Why Mixing Cannabis with Amoxicillin Can Help You Feel Better
Some people may face some adverse effects of amoxicillin, particularly loss of appetite, nausea, and vomiting. Cannabis may help overcome some of these adverse reactions.
The Bottom Line
There seems to be no danger in combining cannabis and amoxicillin. However, if you are not using cannabis for medicinal purposes, it may be wise to stop use for the duration of your treatment to ensure the antibiotic works properly.
See what cannabis can do for you when you obtain a medical marijuana card in your home state. Reach out to Leafwell’s medical team today and start the easy online application process.